1 Larger wheels. I use the bag when commuting downtown or traveling and I never really carry it like a backpack. The larger 3-inch wheels provide a super-smooth ride and I barely feel I'm pulling it. Fantastic! Had I known it would make such a difference, I would have replaced my old bag long ago.
2 Dedicated section/sleeve inside for large laptops. I have a MacBookPro and the pocket in the back is right inside the opening for easy access.
3 Lots of pockets. Traveling with the laptop, I also have to carry around a fair amount of extra hardware and this has plenty of pockets to keep all that stuff organized and still out of the way so I can put the big stuff in the main compartment.
I was only dubious of the single pole handle as it didn't look as sturdy as the 2-pole models. So far though, I've noticed no difference. All in all, a super buy!